In the second column, you'll have seven unused labels, and in the third column, you'll have eleven unused labels. You would enter the four labels in the middle column of the blank template, place the label sheet in the printer with two columns of unused labels (in the correct position), and the four labels you typed would be printed in the middle column. So, if you typed one column of labels and then wanted to come back and type up only four labels, you could do so. When you type a label and leave the next label blank, you'll get what you want when you send the document to your printer. The document you produce on your computer screen will print exactly as it appears on your screen. You get exactly what you see (on your screen). It's WYSIWYG when you type your labels into the Avery label template on your PC. I've always printed complete sheets of labels, but I can tell you from experience that you can print one third of the sheet (one column) or two columns, depending on your needs. Avery 5366 has 50 sheets, while Avery 8366 has 25.